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Has honey different short‐term metabolic effects than glucose:fructose mixtures? A pilot human study
Author(s) -
Despland Camille,
Campos Vanessa,
Walther Barbara,
Kast Christina,
Tappy Luc
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.596.6
Subject(s) - postprandial , fructose , hypertriglyceridemia , triglyceride , chemistry , medicine , insulin resistance , endocrinology , carbohydrate , crossover study , carbohydrate metabolism , insulin , food science , cholesterol , alternative medicine , pathology , placebo
A high fructose diet can cause hypertriglyceridemia and hepatic insulin resistance. In this study, we assessed whether honey may have different metabolic effects than an isomolar glucose:fructose mixture due to its polyphenols and antioxidant content. Eight healthy male volunteers were studied in a randomized, crossover design after 7 days on a weight‐maintenance, low fructose diet (control, C), or on isocaloric diets in which 25% complex carbohydrates were substituted with either acacia honey (HON; fructose:glucose ratio = 1.7) or 15.7% fructose and 9.3% glucose (FG). During all three dietary conditions, a day‐long metabolic profile was obtained, and an oral glucose tolerance test (OGT) with dual glucose isotope (oral 13 C‐ , iv 6,6 2 H 2 glucose) was performed. Fasting triglyceride concentrations were not different between all three conditions (C:1.08±0.25 mmol/L control; HON:1.06±0.26, FG: 0.97±0.24). Postprandial TG responses were higher with HON and FG than with C, but there was no difference between HON and FG. 2‐hour blood glucose concentration during OGT was C:4.1±0.3 mmol/L, HON: 4.6±0.4, and FG: 4.3±0.3 (NS). Suppression of hepatic glucose output after oral glucose was the same in all three conditions (C: ‐69.9±4.4%, HON: ‐72.5±4.1, FG: ‐65.8±5.9, NS). These results indicate that in young healthy male a) consumption of a weight‐maintenance diet containing 25% energy as honey or as a fructose‐glucose mixture slightly increases postprandial triglyceride, but does not alter glucose tolerance nor suppression of hepatic glucose production, and b) the metabolic effects induced by honey and glucose‐fructose are not significantly different.