Premium
Differences in Hormonal Markers of Acne Among Adults with and without Acne
Author(s) -
Burris Jennifer,
Rietkerk William,
Shikany James,
Woolf Kathleen
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.596.10
Subject(s) - acne , insulin resistance , sex hormone binding globulin , medicine , endocrinology , insulin , hormone , dermatology , androgen
Acne is a relatively common skin disease affecting individuals of all ages. Although acne pathogenesis is multifactorial, acne development may be influenced by endocrine changes related to insulin resistance. This study investigated differences in hormonal markers of acne [glucose, insulin, insulin‐like growth factor (IGF)‐1, insulin‐like growth factor binding protein (IGFBP)‐3, and sex hormone binding globulin (SHBG) concentrations] among adults with and without acne. Thirty‐two participants with moderate or severe acne (n=10 males, n= 22 females) and 30 participants with no acne (n=7 males, n=23 females) completed a health history questionnaire, body composition assessment, and fasting blood draw. Insulin resistance was calculated using HOMA‐IR. There were no differences in age, sex, BMI, body composition, glucose, and IGFBP‐3 concentrations between groups. Participants with acne had greater insulin (6±3 uIU/mL) and IGF‐1 concentrations (259±75 ng/mL) and lower SHBG concentrations (62±69 nmol/L) compared to participants with no acne (insulin=4±4 uIU/mL, IGF‐1=216±45 ng/mL, SHBG = 92±80 nmol/L) (p=0.007, p=0.036, and p=0.022 respectively). Participants with acne had greater insulin resistance (1.15±0.67) compared to participants with no acne (0.76±0.79, p=0.004). These results suggest IGF‐1 and SHBG concentrations and insulin resistance may be associated acne development. Future research should investigate interventions focused on reducing insulin resistance and IGF‐1 and increasing SHBG concentrations as potential treatments for acne.