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Urinary sugars excretion as an estimate of sugars intakes is limited in its relationship to cardio‐metabolic risk factors
Author(s) -
Kruimer Devonia,
Te Morenga Lisa,
Mann Jim
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.595.29
Subject(s) - excretion , waist , urinary system , uric acid , fructose , body mass index , endocrinology , medicine , sucrose , orange juice , chemistry , physiology , food science
Background Conclusive evidence on the role of free sugars intakes in cardio‐metabolic disease development is confounded by bias in self‐reported measures of intake. Objective To examine associations between urinary sugars excretion as an objective biomarker for free sugars intakes and cardio‐metabolic risk factors. Methods In an 8‐wk intervention study, participants consumed different beverages (orange juice, sugar sweetened beverages, diet soft drink, or milk). For the analyses we used data of 41 participants. Linear regression was used to examine urinary sugars excretion against body mass index (BMI), waist circumference (WC), and biochemical indicators (CRP, total cholesterol, LDL, HDL, TAG, insulin, uric acid, AST, and ALT). Results Urinary fructose excretion was associated with total cholesterol (B=0.009; p=0.031). Change in urinary sucrose and fructose together was associated with waist circumference (B=0.014; p=0.033). When corrected for baseline measures and sex, the change in urinary sucrose and urinary fructose were not associated with BMI, blood pressure, or percentage body fat, nor was urinary sucrose excretion associated with any of the biochemical indicators. Changes in urinary sugars excretion and self reported values were not associated with treatment (p=0.964 and p=0.536 respectively). Conclusion The results of this study show no convincing evidence for the change in sugars intakes and the association with cardio‐metabolic risk factors.