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Dietary Antioxidants in Relation to Serum CRP in Mid‐Life and Older African Americans
Author(s) -
Rancano Katherine,
Ralston Penny,
Lemacks Jennifer,
Ilich Jasminka
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.588.9
Subject(s) - medicine , confounding , anthropometry , diabetes mellitus , population , c reactive protein , vitamin c , physiology , endocrinology , inflammation , environmental health
Serum CRP is an indirect marker of inflammation and is prominent in the etiology of chronic disease. Racial/ethnic differences in serum CRP may contribute to disparities for chronic disease prevalence in African Americans (AA). Antioxidants mediate inflammation and may reduce risk for chronic disease. Our purpose was to examine the relationship between antioxidant intake (carotenoids, vitamins A, C, E, and selenium) and serum CRP taking into account possible confounders (age, BMI, cardiovascular risk factors, diabetes, smoking, medications, and energy intake)in mid‐life and older AA. The participants included AA men and women >45y ( n =75, 69% women). Self‐administered questionnaires were used to collect data on sociodemographics, perceived health, and medication use. Twenty‐four hour dietary recalls, anthropometric, and biochemical data were collected using standard procedures. Correlation analysis results showed BMI was significantly positively associated with serum CRP (R 2 =0.230, p<0.05). Step‐wise linear regression analysis controlled for confounders, reveled a slight inverse, but nonsignificant, trend for antioxidant intake and serum CRP (vitamin A (RAE) R 2 =‐0.101, carotene R 2 = ‐0.024, vitamin C R 2 = ‐0.057, vitamin E R 2 =‐0.126, and selenium R 2 = ‐0.016). Antioxidants accounted for 2.9% of variance in serum CRP (R 2 =0.029). Although antioxidants did not significantly affect serum CRP in this population, other variables may be influencing the relationship, such as physical activity and gender.