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The Effects of Vitamin E on Hematopoietic Parameters in Ovariectomized Rats
Author(s) -
Pourafshar Shirin,
Johnson Sarah,
Arjmandi Bahram
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.588.13
Subject(s) - ovariectomized rat , medicine , endocrinology , haematopoiesis , vitamin e , oxidative stress , vitamin , hormone , vitamin d and neurology , inflammation , menopause , chemistry , biology , antioxidant , biochemistry , stem cell , genetics
Vitamin E is amongst the most widely used dietary supplements due to its anti‐oxidative and anti‐inflammatory properties and subsequent health benefits. However, its effects on hematopoietic parameters have not been well‐investigated. Ovarian hormone deficiency caused by menopause leads to changes in hematopoietic factors, in part, due to chronic inflammation and oxidative stress. Therefore, vitamin E may be able to ameliorate these changes in hematopoietic‐originated blood cells. For this purpose, we used an ovariectomized (Ovx) rat model to investigate the effects of four doses of vitamin E (75, 300, 525, 750 mg/kg diet) on hematopoietic factors.A total of seventy‐five 12‐month‐old female Sprague‐Dawley rats were either sham‐operated (Sham; 1 group; n = 12) or ovariectomized (Ovx; 4 groups; n = 12) and were given their respective treatments for one‐hundred days. All doses of vitamin E significantly ( P < 0.001) increased mean platelet volume in Ovx rats when compared to Sham (mean values of 6.02 ± 0.14 and 6.46 ± 0.17 in Sham and Ovx, respectively). Ovx resulted in a significant ( P < 0.025) increase in lymphocytes. Vitamin E at 300 mg/kg diet or higher resulted in a significant ( P < 0.048) decrease in neutrophils (mean value of 13.31 ± 3.20 at 300 mg/kg vitamin E). Furthermore, supplementation with 300 and 525 mg/kg diet vitamin E decreased basophils significantly ( P < 0.025). The findings of the present study suggest that vitamin E may have positive effects on hematopoietic parameters after menopause.