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DETERMINANTS OF HIGH PLASMA TRIGLYCERIDE LEVELS: A BRAZILIAN COMMUNITY‐BASED STUDY
Author(s) -
Kano Hugo,
Manda Rodrigo,
Moreto Fernando,
Burini Franz,
Burini Roberto
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.588.1
Subject(s) - triglyceride , quartile , waist , medicine , cardiorespiratory fitness , anthropometry , body mass index , stepwise regression , blood lipids , obesity , endocrinology , body fat percentage , cholesterol , confidence interval
The modern lifestyle, represented by food inadequacy and sedentary behavior is probable the major etiological factor for the burden of contemporary chronic diseases. It is well established that abnormal blood lipids levels appear as a key factor in inflammation and atherogenesis and the management of the altered lipids are directly related to clinical outcomes. This study aimed to analyze the major determinants associated with higher blood triglycerides levels in free‐living adults. In a cross‐sectional study, 582 individuals (80.4 % female), 54.6 + 10.8 years old, were clinically assessed for admission into a lifestyle‐changing program (“Move For Health”). Initially, they were assessed for medical anamneses, blood pressure, physical fitness, body composition/anthropometric (Body Mass Index, Waist Circumference, Body Fat), biochemical (Total cholesterol, HDL‐c, LDL‐c, Gama‐GT, CRP, Triglycerides (TG), Glucose) and cardiorespiratory fitness. Food intake was analyzed by 24h recall questionnaire. TG levels were divided in quartiles for comparison with all co‐variables. ANOVA one way was performed to investigate the difference between triglyceride quartiles followed by Tukey's post hoc. The determinants of TG levels were determinated by Multiple Regression Backward Stepwise (p<0.05). Higher TG levels were associated with higher WC, BMI, glucose, gama gt, CRP, and lower VO2max, weekly physical fitness and HDL‐c. The multiple regression showed that the levels of gama gt ( β :0.34) and CRP ( β : 0.48) were responsible for 51.2% of the high TG levels. Thus, higher plasma TG levels are determined by either obesity and abdominal high adiposity and their consequences, lower aerobic capacity, inflammation and hyperglycemia‐induced stress.