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Vitamin B 6 Status is Associated with Depression Among Women with Inflammation
Author(s) -
Faraj Joycelyn,
Troy Lisa,
BertoneJohnson Elizabeth,
Ronnenberg Alayne
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.587.18
Subject(s) - inflammation , medicine , depression (economics) , vitamin d and neurology , c reactive protein , vitamin d deficiency , gastroenterology , endocrinology , economics , macroeconomics
Depression is the leading cause of disease burden in U.S. women of reproductive age. Inflammation is associated with depression, yet the mechanism for this association remains unclear. Additionally, vitamin B 6 status has been linked to depression and found to be compromised during inflammation. In secondary data analyses, we evaluated the association between inflammation, vitamin B 6 , and depression in non‐pregnant women (19‐45 yrs) from NHANES 2005‐2006. Depression was evaluated with the Patient Health Questionnaire 9 (PHQ‐9); a score of 10 or above denotes clinically significant depression. Inflammation was defined as a C‐reactive protein level above the median (1.8 mg/L). Vitamin B 6 , as plasma pyridoxine‐5′phosphate, was categorized as deficient (<20 nmol/L), insufficient (20‐30 nmol/L) or normal (>30 nmol/L). Overall, 7.7% of women had depression, but this proportion varied by inflammation status: 4.8% of women with no inflammation, compared to 10.4% of women with inflammation had depression (p=0.008). Vitamin B 6 levels were significantly higher (82.1±5.7 vs 54.1±4.6 nmol/L, p=0.005) and PHQ‐9 scores were lower (2.6±0.2 vs 3.7±0.4; p=0.01) in women without inflammation compared to those with inflammation. The PHQ‐9 score for women with no inflammation did not vary by vitamin B 6 status. However, among those with inflammation, women with vitamin B 6 deficiency had significantly higher PHQ‐9 score (6.1±6.8), followed by those with vitamin B 6 insufficiency (3.9±4.9), and those with normal vitamin B 6 status (3.4±4.5) (p<0.01). Understanding the mechanism linking inflammation and vitamin B 6 to depression could lead to new approaches to prevent and treat depression.