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Effects of Alcohol metabolism on Hepatocellular carcinoma progression
Author(s) -
Puszyk William,
Hlady Ryan,
Tiedemann Rochelle,
Robertson Keith,
Liu Chen
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.45.8
Subject(s) - hepatocellular carcinoma , dna methylation , cancer research , epigenomics , epigenetics , biology , methylation , cancer , liver cancer , cpg site , tumor progression , phenotype , carcinoma , alcohol consumption , medicine , alcohol , gene , genetics , gene expression , biochemistry
Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. HCC is known to be a CpG Island methylator Phenotype (CIMP) cancer. Tumor development in CIMP cancers is characterized by epigenomic changes including changes in DNA methylation. We have previously shown that overlapping methylation abnormalities are conserved between primary tissue and cell culture models of HCC. Alcohol consumption is known to increase the risk of development of HCC and has also been shown to alter DNA methylation in a manner that contributes to liver disease. Here we study the effect of alcohol as a driver to tumor progression in HCC. We have developed in vitro models of HCC to identify the gene targets altered by ethanol metabolism during tumor progression over an extended period of time.