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Prospective Study of Vitamin B2 Intake and Colorectal Cancer
Author(s) -
Cho Eunyoung,
Yoon Yeongsook,
Jung Seungyoun,
Zhang Xuehong,
Giovannucci Edward
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.406.4
Subject(s) - medicine , prospective cohort study , hazard ratio , vitamin , colorectal cancer , relative risk , nurses' health study , proportional hazards model , confidence interval , vitamin d and neurology , cohort study , lower risk , environmental health , physiology , cancer
Background Despite the involvement of vitamin B2 to regulate the one‐carbon metabolism and the immune system, only few prospective cohort studies have examined the association between vitamin B2 intake and colorectal cancer (CRC) reporting inconsistent results. Objective To examine the association between vitamin B2 intake and risk of CRC and to evaluate if the association varies by alcohol consumption and folate intake. Design Among 105,628 women and 44,527 men followed up to 2010 in the Nurses' Health Study and Health Professionals Follow‐Up Study, 3,285 cases of incident CRC were identified (2,359 women and 926 men). Vitamin B2 intake was measured by a validated food frequency questionnaire administered every 4 years during follow‐up. To estimate the association between vitamin B2 intake and CRC, Cox proportional hazard models were used to calculate the relative risks (RRs) and its 95% confidence intervals (CIs). Results Vitamin B2 intake was associated with a borderline reduced risk of CRC among women (P trend = 0.03), but not among men (>P trend = 0.73). The multivariate RRs (95% CI) for individuals in the highest quintile of total vitamin B2 intake (from food and supplements) compared to those in the lowest quintile were 0.89 (0.77‐1.03) in women and 0.98 (0.77‐1.23) in men. The associations were similar when stratified by alcohol consumption and folate intake. Conclusions Our results suggest no strong association between high vitamin B2 intake and the risk of CRC. Source of research support : This work was supported by research grants CA136950, CA87969, and CA167552 from the National Institutes of Health.