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Elevations in Serum Anti‐flagellin and Anti‐lipopolysaccharide Immunoglobulins are Related to Underweight in Young Tanzanian Children
Author(s) -
McDonald Christine,
Tran Hao,
Gosselin Kerri,
Manji Karim,
Gewirtz Andrew,
Kisenge Rodrick,
Aboud Said,
Fawzi Wafaie,
Duggan Christopher
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.403.4
Subject(s) - flagellin , underweight , medicine , antibody , lipopolysaccharide , quartile , immunoglobulin a , immunology , immunoglobulin g , overweight , body mass index , confidence interval , receptor
Background Antibodies to lipopolysaccharide (LPS) and flagellin have been described as indirect measures of increased gastrointestinal permeability and may be markers of environmental enteric dysfunction (EED), a condition linked to poor child growth.
Objective To assess whether serum LPS‐ and flagellin‐specific immunoglobulin concentrations are associated with poor growth among young Tanzanian children at risk of EED.
Methods Blood samples were obtained from 590 children at age 6 wks, 6 and 12 mths. Serum LPS‐ and flagellin‐specific immunoglobulin levels (IgA and IgG) were measured by ELISA. Growth was measured monthly for 18 mths.
Results At 6 wks, compared to infants with LPS‐IgA, LPS‐IgG, flagellin‐IgA, and flagellin‐IgG levels in the lowest quartile, those with values in the highest quartile were, respectively, 1.93 (95% CI 1.06, 3.51), 2.89 (1.49, 5.61), 2.09 (1.11, 3.91), and 2.67 (1.38, 5.16) times more likely to become underweight (WAZ <‐2) after adjusting for covariates (p <0.05). These 6 wk markers were not related to the risk of stunting (LAZ <‐2). There was no association between any of the markers at 6 or 12 mths and subsequent underweight or stunting.
Conclusion EED in early infancy, as measured by serum levels of LPS‐ and flagellin‐specific immunoglobulins, is associated with underweight. The relationship between these markers and other EED diagnostic tests requires further study.