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Relationship between Transferrin Receptor and Two Acute Phase Proteins in Women of Reproductive Age
Author(s) -
Addo O.Yaw,
Ashour Fayrouz,
Namaste Sorrel,
Sullivan Kevin,
Suchdev Parminder,
Mei Zuguo,
Rohner Fabian,
NorthropClewes Christine,
FloresAyala Rafael,
Raiten Daniel
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.393.4
Subject(s) - acute phase protein , transferrin receptor , inflammation , ferritin , soluble transferrin receptor , transferrin , medicine , biomarker , c reactive protein , odds ratio , anemia , ceruloplasmin , immunology , iron deficiency , iron status , biology , biochemistry
Transferrin receptor (TfR) is a biomarker for iron reported to be less affected by inflammation compared to ferritin. We examined the associations between two acute phase proteins (APP), α‐1‐acid glycoprotein (AGP) and C‐reactive protein (CRP), with TfR. A multi‐national database of 8,410 non‐pregnant women aged 15‐49 y from 6 countries (USA, Laos, Ivory Coast, Cameroon and Papua New Guinea) as part of the Biomarkers Reflecting Inflammation and Nutrition Determinants of Anemia (BRINDA) project was analyzed. Elevated TfR was defined as >8.3 mg/L, elevated CRP >5 mg/L, and elevated AGP >1 g/L. Prevalence of elevated TfR was 20.0%, ranging from 5.7% in Laos to 33.8% in Cameroon. Correlations between APP and TfR ranged from 0.01 – 0.27. Based on preliminary analyses, women with elevated AGP had a higher prevalence of elevated TfR [overall prevalence odds ratio (POR) 2.0 (95%CI: 1.6–2.5), with the strongest association in Laos where the POR was 3.1(1.5–6.7). Elevated CRP was not associated with elevated TfR in any country, except USA. When modeling both AGP and CRP as predictors, the POR for elevated TfR was higher for AGP but it remained non‐significant for CRP. Inflammation, as measured by elevated AGP but not CRP, is associated with TfR in women of reproductive age and thus may overestimate the prevalence of elevated TfR. In this presentation various approaches to account for inflammation in their relationship with TfR will be presented. Funding:Gates Foundation, CDC, GAIN, NICHD.