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A Healthy Lifestyle Score is Associated with Inflammation Markers among Puerto Rican Adults
Author(s) -
SotosPrieto Mercedes,
Bhupathiraju Shilpa,
Falcon Luis,
Gao Xiang,
Tucker Katherine,
Mattei Josiemer
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.393.2
Subject(s) - confounding , medicine , inflammation , obesity , diabetes mellitus , interleukin 6 , tumor necrosis factor alpha , disease , sedentary lifestyle , systemic inflammation , c reactive protein , gerontology , endocrinology
The role of multiple lifestyle components analyzed in combination on inflammatory markers remains understudied. We aimed to assess the association between a Healthy Lifestyle Score (HLS) that includes five behavioral components (diet, physical activity and sedentary behaviors, smoking, social support and network, and sleep) and inflammatory markers in Puerto Rican adults. In a cross‐sectional study, the HLS, ranging from 0 (unhealthy) to190 (healthiest), was developed in 842 Puerto Ricans living in Boston (aged 45‐75 y). Multivariable‐adjusted models were used to test association between the HLS and biomarkers of inflammation. The HLS was inversely associated with interleukin (IL)‐6 (β±SE =‐0.55 ± 0.13; P <0.001) and tumor necrosis factor‐alfa (TNFα) (‐0.39 ± 0.13; P =0.004) after adjustment for potential confounders. The dietary and the smoking components of the HLS were independently associated with inflammatory markers. Significant inverse associations were observed for each 20‐unit increase in HLS and IL‐6 and TNFα for participants with hypertension (‐0.57 ± 0.17; ‐0.35 ± 0.17, respectively) and with obesity (‐0.56 ± 0.14; ‐0.48 ± 0.15, respectively), but not for those with diabetes or heart disease. The HLS was not associated with C‐reactive protein, after adjustment for potential confounders. In conclusion, higher adherence to multiple lifestyle behaviors was associated with lower concentrations of biomarkers of inflammation. Because hypertension and obesity may be mediated through inflammation, following an overall healthy lifestyle may help reduce risk of these diseases.