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Caffeine, coffee and tea in relation to risk of hip fracture in The Singapore Chinese Health Study
Author(s) -
Dai Zhaoli,
Yuan JianMin,
Koh WoonPuay
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.392.8
Subject(s) - medicine , caffeine , hazard ratio , confidence interval , prospective cohort study , proportional hazards model , hip fracture , cohort study , lower risk , demography , osteoporosis , sociology
The dosage of caffeine or coffee in relation to risk of osteoporotic fractures is unclear. In this study, we examined the associations between intake of caffeine, coffee or tea and risk of hip fracture in the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women (45‐74 years) recruited in 1993 ‐ 1998. At baseline, habitual diet including coffee and tea was assessed by a validated food frequency questionnaire. Multivariate Cox proportional regression model was used to estimate hazard ratio (HR) and its 95% confidence interval (CI). During a mean follow‐up of 9.9 years, we identified 1,630 hip fracture incident cases. Compared with drinking coffee <1cup/d, drinking 蠅3 cups/d increased risk for overall (HR: 1.31, 95% CI: 1.04, 1.64) as well as for men and women separately, whereas drinking 2 cups/d reduced risk in women (HR: 0.86, 95% CI: 0.74, 1.02) but not in men (HR: 1.14, 95% CI: 0.89, 1.45). For daily caffeine intake, women with 200‐<300mg had 14% risk reduction compared to those with<100mg (p<0.05), but not in men. In combined analysis, compared to caffeine <200mg/d, for those with 蠅200mg/d, the risk was reduced in women who drank coffee <3cups/d (HR: 0.85, 95% CI: 0.74, 0.99), but was increased in women who had coffee 蠅3cups/d (HR: 1.32; 95% CI: 1.00, 1.73). Drinking tea was not related to risk of hip fracture. We concluded that daily caffeine 200‐<300 mg or drinking 2 cups/d of coffee may reduce hip fractures in women. However, taking coffee 蠅3 cups/d posed risk in both genders, indicating possible detrimental effects of other compounds from coffee on bone health.