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Protective Association of Serum Uric Acid on Hip Fracture Risk among Older Men But Not Women
Author(s) -
Sahni Shivani,
Mangano Kelsey,
Tucker Katherine,
Fox Caroline,
Kiel Douglas,
Dufour Alyssa,
Zhang Xiaochun,
Hannan Marian
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.383.7
Subject(s) - medicine , hazard ratio , uric acid , hip fracture , cardiology , confidence interval , osteoporosis
Objective To examine the association of serum uric acid (UA) with hip fracture (fx) risk over a 20y follow‐up in older adults from the Framingham Heart Study. UA is an antioxidant within normal levels and may act as a pro‐oxidant at higher levels. We examined associations within categories of UA: normal physiological levels of UA (蠄7.2 men; 蠄6.2 mg/dl women) and high UA Methods 2779 men and women with baseline UA (mg/dl, in 1973‐76) were followed for hip fx through 2009. Sex‐stratified Cox‐proportional hazards regression estimated adjusted Hazard Ratios (HR). We examined associations stratified by UA categories. Results At baseline mean age was 66y, UA (mg/dl) was 5.9±1.2 (men); 4.9±1.3 (women). 353 hip fx occurred over 20y follow‐up. UA level was not related with hip fx risk in men or women [HR(95%CI): 0.92(0.76‐1.11) men; 1.01(0.92‐1.11) women]. Upon stratification by UA category, there was 22% lower hip fx risk (P=0.05) per unit increase in UA in men with UA蠄7.2 mg/dl, but no significant association in men with higher UA or in women with normal/higher UA. Conclusion Within normal range of UA (蠄7.2 mg/dl), greater concentrations were associated with reduced hip fx risk in older men suggesting that UA may be acting as an antioxidant within this range. At higher concentration, UA may act as a pro‐oxidant but there was limited power in that sub‐group to see an effect. It is unclear why no association was seen in women. Future work should examine UA (normal and high) in relation to bone measures in larger studies.Funding ASBMR JFOR201314, NIH/NIAMS R03 AR062808, NIH AR053205; FHS N01‐HC‐25195 R01 AR/AG41398.