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Effect of the Intake of High‐SDS Product on Metabolic and Inflammatory Markers in Healthy Subjects with High Metabolic Risk
Author(s) -
Meynier Alexandra,
LambertPorcheron Stéphanie,
Normand Sylvie,
Roth Hubert,
Laville Martine,
Vinoy Sophie
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.379.7
Subject(s) - postprandial , glycemic , ingestion , food science , medicine , lipid profile , oxidative stress , glycemic index , overweight , metabolic syndrome , diabetes mellitus , endocrinology , obesity , chemistry
Objectives The comparison of metabolic and inflammatory responses following the ingestion of cereal products high in Slowly Digestible Starch (SDS) was studied in subjects with impaired glucose tolerance. Methods In a cross‐over design, 20 (13F/7M) healthy overweight subjects with high metabolic risk participated to 3 sessions: one session testing a glucose solution (54g which is the amount of carbohydrates provided by the two other breakfasts), two sessions testing either a biscuit high in SDS or a rusk without SDS with 250 mL of semi‐skimmed milk and a hot beverage. The 2 sessions with cereal products followed a 3‐week period where the corresponding cereal product was daily consumed. Glycemia, insulinemia, blood lipid profile and markers for inflammation and oxidative stress were followed during a 240‐minute postprandial period. Results Glycemic responses following both cereal products were lower compared to glucose solution. iAUC(0‐120 min) glycemia was significantly lower (‐32 %) following the breakfast with biscuit high in SDS compared to rusk without SDS. The insulinemic response was also lower following the breakfast with the biscuit compared to the 2 other sessions. No significant difference was observed between the 2 groups with cereal products for blood lipid profile and for the makers of inflammation and oxidative stress. Conclusion Breakfast with a high‐SDS biscuit led to lower glycemic and insulinemic responses compared to breakfast including a rusk with no SDS in subjects with high metabolic risk. The ingestion for 3 weeks of the cereal products did not modified fasting and postprandial markers of inflammation and oxidative stress.