Premium
Metabolic Fate of a Fructose Load Ingested Before or After Exercise
Author(s) -
Egli Leonie,
Lecoultre Virgile,
Rosset Robin,
Cros Jeremy,
Tappy Luc
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.379.4
Subject(s) - fructose , ingestion , medicine , endocrinology , chemistry , fructolysis , metabolism , glycogen , biochemistry
Exercise prevents fructose‐induced hypertriglyceridemia, however the mechanisms remain unknown. To assess how exercise impacts fructose metabolism, we monitored the metabolic fate of an oral 13 C fructose load consumed either before or after an exercise session. Eight healthy males were studied on 3 occasions after 4 days on a weight‐maintenance high fructose diet. In each condition, they ingested an oral 13 C‐labelled fructose load (0.75 g/kg body weight) either a) in resting condition ( C ), b) with an exercise session ( FruEx ; 60 min cycling at 100 W) performed 90 min after fructose ingestion, or c) with the same exercise session performed 75 min before ingestion ( ExFru ). On each occasion, fructose oxidation ( 13 CO 2 ), non‐oxidative fructose disposal (NOFD; fructose ingestion – 13 C fructose oxidation, corresponding to net glycogen synthesis), conversion of fructose into plasma glucose ( 13 C‐plasma glucose kinetics) and plasma lactate concentrations were measured over 7 hours after fructose loading. In C , 49.4±0.9 % of fructose was oxidized, and NOFD represented 50.6±0.9%. FruEx increased fructose oxidation by 68±7% (p<0.001) and decreased NOFD by 64±6% (p<0.001) compared to C . In ExFru, fructose oxidation (‐3±3%vs C; p=NS), and NOFD (+1±3%; p=NS) remained unchanged. In both FruEx and ExFru , fructose conversion into glucose and lactate concentrations remained unchanged as compared to C . We conclude that exercise performed after fructose ingestion diverts fructose from NOFD by enhancing its oxidation, while exercise performed before fructose ingestion does not significantly alter fructose disposal This work was supported by the Swiss National Science Foundation.