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Differential Responses to Hormone Therapy Among ER+/PR+/HER2‐ Breast Cancers That Differentially Express the Estrogen Response Signature
Author(s) -
Sandhu Rupninder,
Parker Joel,
Anders Carey,
Coleman William
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.284.7
Subject(s) - medicine , breast cancer , oncology , estrogen , estrogen receptor , her2 negative , hormone therapy , cancer , metastatic breast cancer
ER+/PR+/HER2‐ breast cancers are frequently associated with good outcomes, but some patients experience disease progression/recurrence. We examined responses to hormone therapy (HT) in 182 ER+/PR+/HER2‐ breast cancers (with known molecular subtype) that differentially express a 583‐gene estrogen response signature (ERS). Overall, 13/33 (39%) patients treated with HT relapsed versus 77/149 (52%) untreated patients. 142 ER+/PR+/HER2‐ breast cancers are ERS+ (27% relapse with HT, 48% untreated relapse), and 40 ER+/PR+/HER2‐ breast cancers are ERS‐ (100% relapse with HT, 62% untreated relapse). Kaplan‐Meier analysis revealed a significant improvement in relapse‐free survival among ERS+ ER+/PR+/HER2‐ breast cancers that received HT versus untreated (P=0.0489). ERS+ ER+/PR+/HER2‐ Luminal A breast cancers benefit from HT – 5/19 (26%) treated relapsed versus 36/75 (48%) untreated relapsed. ERS+ ER+/PR+/HER2‐ Luminal B (LumB) breast cancers show less benefit from HT – 1/3 (33%) treated relapse versus 12/29 (41%) untreated relapse. Any HT benefit observed is lost among ERS‐ ER+/PR+/HER2‐ LumB breast cancers – 5/5 (100%) treated relapse versus 10/17 (59%) untreated relapse. ER+/PR+/HER2‐ HER2‐enriched breast cancers do not benefit from HT – Over 50% relapse irrespective of ERS or HT status. Despite small numbers, ERS+ ER+/PR+/HER2‐ Basal‐like and Claudin‐low breast cancers appear to show benefit from HT – 0/3 (0%) treated relapse versus 4/6 (67%) untreated relapse. Most molecular subtypes of ERS+ ER+/PR+/HER2‐ breast cancer benefit from HT.