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Effects of Pre‐conceptual Micronutrient Supplementation on Maternal Depression in Vietnamese Women
Author(s) -
Ramakrishnan Usha,
DiGirolamo Ann,
Nguyen Phuong,
GonzalezCasanova Ines,
Nguyen Hieu,
Pham Hoa,
Truong Truong,
Nguyen Son,
Martorell Reynaldo
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.28.1
Subject(s) - micronutrient , pregnancy , medicine , malnutrition , vietnamese , depression (economics) , randomized controlled trial , obstetrics , gynecology , biology , linguistics , philosophy , genetics , macroeconomics , pathology , economics
Micronutrient malnutrition has been associated with maternal depressive symptoms (MDS), but little is known about the effects of pre‐conceptual micronutrient supplementation. We examined the effects of pre‐conceptual micronutrient supplementation on MDS during pregnancy and postpartum using data from a double‐blind controlled trial (PRECONCEPT) in which 5011 Vietnamese women were randomized to receive weekly supplements containing either a) multiple micronutrients MM b) iron and folic acid IFA or c) folic acid FA until conception, followed by daily IFA supplements through delivery. Maternal depression was assessed using CES‐D at baseline and 12 m post‐partum and the EPDS during pregnancy and 3 m postpartum. The proportion of women ever experiencing elevated MDS during pregnancy (n=1616), postpartum (n= 1465) was 17.8% and 5.4%, respectively. No significant differences were seen by treatment. Among women at risk for depression at baseline (CES > 10; n=157), 29.1 and 30.1% experiencing elevated MDS during pregnancy in the MM and IFA groups, respectively, compared to 48.1% for FA only (p=0.07 for interaction). These relationships were attenuated (RR = 0.45, 95% CI: 0.2, 1.02 for MM vs FA and RR=0.47, 95% CI: 0.21, 1.06 for IFA vs FA) after adjusting for differences in age at marriage and serum ferritin between treatment groups. These findings suggest that women at risk for depression before they conceive may benefit from pre‐conceptual micronutrient supplements containing iron. Funded by Mathile Institute, Micronutrient Initiative, and Nestle Foundation.