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Apple Consumption Protects Sprague Dawley Rats Against High Fat Diet‐induced Metabolic Disorders Associated With Obesity
Author(s) -
yuan jialing,
chew Boon,
noratto giuliana
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.276.7
Subject(s) - obesity , tbars , metabolic syndrome , adipose tissue , body mass index , calorie , medicine , endocrinology , chemistry , food science , lipid peroxidation , oxidative stress
Apples contain non‐digestible compounds including fiber and phenolics reported for their benefits associated with prevention of chronic diseases. Our objective was to investigate the effects of apple consumption in prevention of obesity and obesity‐related metabolic disorders in vivo . Freeze dried Granny Smith apple previously identified for its enhanced content of non‐digestible bioactive compounds was used to supplement a high fat diet at 7% (60% calories from fat, HFA), the control HF was supplemented with corn starch to maintain isocaloric diets. Sprague Dawley rats were fed ad libitum for 6 weeks. The collected blood and adipose tissues at the end of study were analyzed for biomarkers of obesity, inflammation, and metabolic disorders using standard analytical procedures. Results show that body mass index (BMI) data distribution in HFA was below the lower interquartile range of HF group. Adiposity index values were significantly lower in HFA (4.1%) compared to HF group (7.7%). Apple consumption improved significantly glucose tolerance by decreased area under curve in 8% compared to HF. This was correlated with decreased plasma total cholesterol from 190.4 to 159 mg/dL, triglycerides from 72.6 to 54 mg/dL, thiobarbituric acid reactive substances (TBARS) from 71.31 µM to 40.90 µM. Overall, these results strongly indicate that apple consumption can protect from development of metabolic disorders associated with obesity. We are currently investigating the relationship between plasma metabolic and inflammatory makers and changes in fecal bacteria.