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THE EFFECT OF A LOW GLYCEMIC INDEX DIET ON DIABETIC NEPHROPATHY
Author(s) -
Srichaikul Korbua,
Hertzog Valerie,
Dutton Heidi,
Kendall Cyril,
Sievenpiper John,
Jenkins David
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.274.7
Subject(s) - microalbuminuria , medicine , glycemic , diabetes mellitus , creatinine , urine , type 2 diabetes , glycemic index , endocrinology , urology
Background Microvascular complications, including renal disease, have been strongly associated with poor glycemic control. We have therefore assessed the effect of improved glycemic control after consumption of a low glycemic index diet on the degree of microalbuminuria. Methods 155 type 2 diabetic subjects treated with antihyperglycemic agents were randomized and completed either 6 months of high fiber or low glycemic index dietary advice in a parallel design. In 150 completers, 24 hour urine collections were obtained pre‐treatment and at the end of the 6 month study period. Results A total of 107 subjects had detectable albumin in their baseline 24 hour urine collections with 14 subjects having microalbuminuria (urinary albumin >30 mg/24 hours). The treatment difference in the change in microalbuminuria was not significant. However, with improved glycemic control on the low glycemic index diet microalbuminuria decreased by 63±24 mg/d (n=7, p=0.039) compared to a reduction of 15±13mg/d (n=7, p=0.308) on the high fiber diet. No between treatment difference was seen in serum creatinine or creatinine clearance. Conclusion These preliminary data suggest a possible benefit of low glycemic index diets on microalbuminuria in type 2 diabetes. Funding the Canadian Institutes of Health Research, Canada Research Chair Endowment of the Federal Government of Canada, and Barilla (Italy).