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Effect of a Family Based Intervention on Biomarkers of Diet Quality/Endogenous Metabolism and change in BMI z‐score
Author(s) -
Matthan Nirupa,
Xue Xiaonan,
Gao Qi,
WylieRosett Judith,
Lichtenstein Alice
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.274.6
Subject(s) - medicine , lutein , biomarker , lycopene , odds ratio , polyunsaturated fatty acid , carotenoid , food science , endocrinology , chemistry , biochemistry , fatty acid
The objective was to assess the effect of a family‐based weight management intervention on biomarkers of diet quality/endogenous metabolism and cardiometabolic risk in children (7‐12 years; N=309) with baseline BMI z‐score (BMIz) > 85 th percentile. Families were randomized to a control (receiving standard care) or an experimental group (receiving targeted diet/physical activity strategies). Biomarkers were measured using GC or HPLC. After 1 year, significant decreases in BMIz (‐7%), LDL‐C (‐3%) and liver enzymes (‐3%) and increases in HDL‐C (2.3%) were observed in both groups, thus groups were subsequently combined. Among the dietary biomarkers, there were significant decreases in total trans (‐13%) and lutein (‐3%), and increases in omega‐3 fatty acids (18:3n‐3, 26%; 20:5n‐3, 16%; 22:5n‐3, 9%; 22:6n‐3, 7%). Using multivariate logistic regression (odds ratios per 10% increment in biomarker [95% CI]), total trans (1.2 [1.0‐1.4]), partially‐hydrogenated fat biomarker, lutein (1.1 [1.03‐1.13]) and lycopene (1.09 [1.03‐1.15]), egg and tomato‐based food biomarkers, were positively associated with change in BMIz. MUFA 16:1n‐7 (0.83 [0.72‐0.96]), indicator of de novo lipogenesis, was negatively associated, while stearoylCoA desaturase (1.53 [1.03‐2.26]), the rate limiting enzyme in MUFA synthesis, were positively associated with change in BMIz, respectively. Results suggest that foods high in trans fat and tomato‐based products (e.g., pizza) have an adverse effect on change in BMIz. Likewise biomarkers of in vivo metabolism were predictive of change in BMIz in this cohort of high‐risk children.