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Components of a Mediterranean Diet are Associated with Gut Permeability in Obese Adults
Author(s) -
Moss Olivia,
Keshavarzian Ali,
Tangney Christy,
Shawron Krista,
Kester Kelly,
Clifford Kerry,
Piazza Bryana,
Shaikh Maliha,
Betz Melanie,
Rasmussen Heather
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.262.2
Subject(s) - sucralose , lactulose , intestinal permeability , sugar , mediterranean diet , sucrose , food science , medicine , chemistry
Increased gut permeability allows translocation of inflammatory microbiota products into the host system. However, it is unknown how dietary patterns and their components impact permeability. Therefore, the objective was to determine if a Mediterranean dietary (MedDiet) pattern is associated with gut permeability. In this cross‐sectional study, urine was collected after a sugar challenge (mannitol, sucrose, sucralose, lactulose) in 32 obese (BMI, mean ± SD; 37.0 ± 6.0 kg/m 2 ) adults aged 47.0 ± 10.9 yrs; 59% were African American and 81% were female. Collections at the 5‐ and 24‐hr time points were analyzed. All completed a 16‐component MedDiet screener. Median (IQR) overall MedDiet score was 8 (6, 9). There were no differences in permeability (% oral sugar dose excreted; Mann Whitney U) observed between those assessed as MedDiet accordant (蠅 8) vs those not accordant. Those accordant to the green leafy vegetable, berries, red meat, chicken, beans, sweets, and fast‐food subcomponents had lower permeability than those not accordant; most notably, gastro‐duodenal (5‐hr sucrose; 0.22 [0.14, 0.75] vs 0.42 [0.25, 0.73]), small bowel (5‐hr lactulose; 0.56 [0.31, 0.75] vs 0.84 [0.61, 1.4]), and total gut permeability (24‐hr sucralose; 0.37 [0.21, 1.00] vs 0.86 [0.54, 1.82]) was lower in those accordant vs those not accordant to the berries subcomponent. Accordance to the fast‐food subcomponent had lower total gut permeability, with greater than a two‐fold difference in 24‐hr sucralose:lactulose between accordance and non‐accordance (0.16 [0.08, 0.36] vs 0.40 [0.24, 0.57]). While exploratory, these data suggest that specific subcomponents of a MedDiet may be protective to the intestinal barrier.