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Low sodium intake is associated with higher HDL cholesterol in premenopausal Filipino women
Author(s) -
Lee Nanette,
Duazo Paulita
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.260.8
Subject(s) - medicine , confounding , triglyceride , cholesterol , odds ratio , endocrinology , sodium , blood lipids , zoology , chemistry , biology , organic chemistry
Low sodium (Na) intake is known to reduce hypertension risk, but some studies suggest that it can have a deleterious effect on cardiovascular disease (CVD) risk due to adverse effects on blood lipids. We examined the association between Na intake and blood lipids [total, low density, and high density cholesterol (TC, LDL, HDL) and triglyceride (TG)] in 1,865 Filipino women (age 35‐69 y) and assessed whether the association differed by menopausal status using data from the 2005 Cebu Longitudinal Health and Nutrition Survey. In addition, to estimate possible long‐term effects, we examined the association between Na intake in 2005 and lipid levels (TC and HDL) in 2012. Na intake was on average about 2,900 mg/day and categorized into: low if <1,500mg/day (26%), moderate if 1,500 to <2,500 mg/day (28%) and high if >=2500 mg/day (46%). Salty condiments added during cooking or at the table accounted for 76% of Na intake. Regression analyses adjusting for age, BMI and other confounders showed that low Na intake had favorable effects on HDL levels but only among premenopausal women: compared to moderate Na intake (reference), those with low intake had 1.88 mg/dL (95% CI: 0.3, 3.46) higher HDL and 32% lower odds [OR 0.68 (0.49, 0.95)] of having low HDL (<40 mg/dL). Similar results are seen when estimating the effect of low Na intake in 2005 on HDL in 2012: low intake is associated with 2.79 mg/dL (0.5, 5.09) higher HDL and lower odds of low HDL [OR 0.61 (0.43, 0.87)]. No significant associations were observed for other lipids. Thus, no adverse effects of low Na intake on blood lipids but rather a potentially beneficial effect on HDL levels of premenopausal women were found among Filipino women. Results support efforts to reduce sodium consumption to lower CVD risk in the country. Funding: NIH 5R01AG039443