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The Effect of Vitamin D Supplementation on Glucose Homeostasis among African Americans and Hispanics with Type 2 Diabetes
Author(s) -
Exebio Joel,
Zarini Gustavo,
Vaccaro Joan,
Ajabshir Sahar,
Huffman Fatma
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.259.8
Subject(s) - medicine , endocrinology , vitamin d and neurology , glucose homeostasis , type 2 diabetes , insulin , diabetes mellitus , cholecalciferol , impaired fasting glucose , vitamin d deficiency , vitamin , hemoglobin , prediabetes , insulin resistance , impaired glucose tolerance
The aim of the present study is to determine the effect of supplemental vitamin D intake (4000 IU or 6000 IU of cholecalciferol daily for 6 months) on fasting plasma glucose, fasting insulin, and glycosylated hemoglobin (A1C) in a sample of African Americans and Hispanics with type 2 diabetes and vitamin D insufficiency. Seventy five participants were recruited by community outreach. Plasma glucose concentration was measured by hexokinase enzymatic method. A1C was measured by the DCA2000+ system. Insulin in fasting blood was determined by radioimmunoassay. Serum vitamin D concentrations were measured with an enzyme‐immunoassay kit. General lineal model was used to compare treatment effects and Bonferroni multiple comparison tests was used to detect significant changes from baseline, 3 months, and 6 months on the outcome variables. No significant changes were observed for fasting plasma glucose, insulin or A1C between groups and within groups. Vitamin D supplementation did not improve glucose homeostasis in this sample. Funding for this research was provided through an NIH/NIDDK sponsored grant.