Premium
Acute Peanut Consumption Benefits Postprandial Endothelial Function in Overweight Healthy Males
Author(s) -
Liu Xiaoran,
Hill Alison,
West Sheila,
Gabauer Rachel,
McCrea Cindy,
Fleming Jennifer,
KrisEtherton Penny
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.259.6
Subject(s) - postprandial , medicine , triglyceride , meal , overweight , hyperlipidemia , endothelial dysfunction , insulin , cholesterol , endocrinology , obesity , diabetes mellitus
Endothelial dysfunction is important in the onset and progression of atherosclerosis. Postprandial hyperlipidemia is associated with an impairment (i.e. reduction) of endothelial function. We evaluated the effect of acute peanut consumption on postprandial lipids and endothelial function as assessed by flow‐mediated dilatation (FMD) of the brachial artery in fifteen overweight males (BMI 31.4±0.8). Participants were randomized to either a peanut meal contain 3 oz. of ground peanuts (1198 kcal, 40.0% CHO, 47.7% FAT: 19.4% SFA, 13.2% PRO) or a control meal with matched energy and macronutrients, followed by the alternative meal scheduled at least one week apart. The meals were delivered as shakes. The lipid profile, glucose and insulin were measured postprandially at baseline, 0.5, 1, 2, and 4h. FMD was measured at baseline and at 4h. Acute peanut consumption resulted in a blunted triglyceride response 2h after consumption compared with the control meal (94.5±13.4 mg/dL vs. 117.1±13.4 mg/dL, p=0.034). The change in total cholesterol, LDL‐cholesterol, HDL‐cholesterol, glucose and insulin was similar between the test meals. Compared to baseline, the control meal decreased FMD at 4h (‐1.2%±0.5, p=0.03), whereas no significant difference was observed after consumption of the peanut meal (‐0.6%±0.5, p=0.3). The present study demonstrated that the inclusion of peanuts (3 oz.) as part of a high fat meal improved the postprandial triglyceride response and preserved endothelial function. Support: the Peanut Institute; Clinicaltrials.gov identifier NCT01405300