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Plasma Zinc Correlations with Markers of Inflammation in Overweight and Obese Adults; a Cross Sectional Phenotyping Study
Author(s) -
Woodhouse Leslie,
Adams S.,
Keim N.,
Van Loan M.,
Zunino S.
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.258.7
Subject(s) - adiponectin , medicine , endocrinology , leptin , obesity , overweight , insulin , adipokine , body mass index , metabolic syndrome , c reactive protein , insulin resistance , inflammation
Obesity is associated with chronic low‐grade systemic inflammation which is characterized by increased levels of circulating pro‐inflammatory and cardiometabolic risk markers. Studies have reported lower circulating zinc (Zn) levels with obesity, and other studies have not. More research is needed to determine the mechanisms involved in the low Zn phenotype associated with obesity, and a cross sectional study looking at obesity, inflammatory markers and plasma Zn will determine potential correlations to aid in the understanding of how obesity affects Zn status. Adults (19‐60 years; BMI 25‐46 kg/m 2 ) were recruited (n=228; 53 men, 175 women) for 6 nutritional intervention studies. Exclusion criteria included vegetarian diet, high blood pressure, high fasting glucose, and lipid or cholesterol lowering medications. Baseline measures included BMI, DEXA for fat mass (FM) and lean body mass (LM), fasting plasma Zn, & inflammatory (IL1‐β, IL‐6, IL‐8, TNF‐α, hsCRP) & metabolic (insulin, leptin, PAI‐1, & adiponectin) markers. Plasma Zn correlated positively with LM & PAI‐1, and negatively with leptin. Leptin correlated positively with BMI, FM, CRP, insulin, and negatively with LM and Zn. Insulin correlated positively with FM, BMI, IL‐1β, IL‐6, TNF‐α and leptin, and negatively with adiponectin. A stepwise multiple regression model showed that 28% of the variance in fasting plasma Zn can be explained by LBM, CRP, insulin and adiponectin. 32% of the subjects had lower Zn status based on iZiNCG criteria, and this group showed no difference in body composition, but had higher levels of inflammatory markers. With obesity studies it is important to determine body composition & inflammatory & cardiometabolic markers in order to further elucidate Zn status.