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Alternate‐day fasting and daily calorie restriction similarly affect visceral adiposity and circulating inflammatory cytokine concentrations
Author(s) -
Trepanowski John,
Kroeger Cynthia,
Barnosky Adrienne,
Hoddy Kristin,
Varady Krista
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.254.2
Subject(s) - resistin , adiponectin , medicine , leptin , endocrinology , overweight , calorie , intermittent fasting , insulin , calorie restriction , cytokine , obesity , adipokine , insulin resistance
Background Visceral obesity is associated with dysregulated inflammatory cytokine secretion. We tested the hypothesis that alternate‐day fasting (ADF) would preferentially reduce visceral fat mass and normalize circulating inflammatory cytokines compared to daily calorie restriction (CR). Methods Overweight and obese subjects (n = 62) were randomized to 1 of 3 groups for 24 weeks: 1) ADF (feed day: 125% of energy needs, alternated with a fast day: 25% of energy needs; all meals provided); 2) CR (75% of energy needs every day; all meals provided); 3) Control (100% of energy needs every day; self‐selected diet). Results Changes in visceral fat mass and concentrations of all measured circulating inflammatory cytokines were similar among all three groups (p > 0.05 for all comparisons). After pooling together the data from the dietary intervention groups, C‐reactive protein decreased relative to the control group (0.19 mg/dl; p < 0.02), while insulin‐like growth factor 1 decreased in the control group relative to the dietary intervention groups (24 ng/ml; p < 0.03). There were no changes between the dietary intervention groups and the control group for tumor necrosis factor α, interleukin 6, adiponectin, leptin, or resistin (p > 0.05 for all comparisons). Conclusion ADF and CR produce similar changes in C‐reactive protein and insulin‐like growth factor‐1 relative to a control group.