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A 1 H NMR‐Based Approach to Investigate Metabolomic Differences in the Plasma and Urine of Young Women after Cranberry Juice or Apple Juice
Author(s) -
Liu Haiyan,
Tayyari Fariba,
Khoo Christina,
Gu Liwei
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.249.3
Subject(s) - cranberry juice , metabolome , chemistry , hippuric acid , metabolomics , urine , food science , fruit juice , urinary system , chromatography , biochemistry , medicine
The present study aimed to investigate overall metabolic changes caused by cranberry juice or apple juice consumption using a global 1 H NMR‐based metabolomics approach. Eighteen female college students, between 21‐29 years old, were given either cranberry juice or apple juice for three days using a cross‐over design. Plasma and urine samples were collected before and after juice consumption. Metabolome in urine and plasma were analyzed using 1 H NMR‐based metabolomics followed by multivariate analyses. No metabolic difference was observed in human plasma before and after juice consumption for either cranberry or apple juices. However, metabolome in plasma and urine after cranberry juice consumption were different from those after apple juice consumption. Cranberry juice consumption caused a greater increase in urinary excretion of hippuric acid and a higher level of citric acid in the plasma. On the other hand, cranberry juice decreased the plasma level of lactate, D‐glucose, and two unidentified metabolites compared to apple juice consumption. The metabolomic changes caused by cranberry juice consumption may help to explain its reported health benefits. This research is supported in part by Ocean Spray Cranberries, Inc.