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Early Life Microbiome, Obesity and Diabetes
Author(s) -
Blaser Martin
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.222.1
Subject(s) - biology , immune system , microbiome , obesity , gut flora , diabetes mellitus , metabolic syndrome , antibiotics , immunology , feces , zoology , bioinformatics , microbiology and biotechnology , endocrinology
The congruence of the phylogenies of hominid hosts and their fecal microbiota provide strong evidence for vertical microbiota transmission extending for millions of years. Increasing evidence indicates that the vertically transmitted early life microbiota in mammals is involved in the choreography of host metabolic and immune development. We have used mouse models to assess microbiota roles in development, using perturbation by antibiotics as an experimental tool. Compared to untreated mice, we have found evidence for changes in microbiota diversity and community structure and metabolic activities, as well as changes in host intestinal and hepatic gene expression, immune cell populations, adiposity, and metabolic diseases. These murine models permit analysis of how antibiotic perturbations early in life predispose to obesity, metabolic syndrome, and diabetes in humans.