Premium
Microengineered Physiological Biomimicry: Human Organs‐on‐Chips
Author(s) -
Huh Dan
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.13.4
Subject(s) - biomimetics , nanotechnology , materials science
Human organs are complex living systems in which specialized cells and tissues are assembled in various proportions and patterns to carry out integrated functions essential to the survival of the entire organism. Lack of reliable model systems that recapitulate the complexity of living human organs poses major technical challenges in virtually all areas of life science and technology. This talk will present interdisciplinary research efforts focused on leveraging unique capabilities of microfluidics and microfabrication to develop microengineered biomimetic models that reconstitute complex structures, dynamic microenvironments, and physiological functionality of human organs. Specifically, I will talk about i) a bioinspired microsystem that mimics the structural and functional complexity of the alveolar‐capillary interface in the living human lung , ii) a specialized in vitro human disease model that simulates pulmonary edema, and iii) a microengineered model of the ocular surface in the human eye.