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Endocrine response in administration of 5‐HT1A agonist associated with E2 replacement in ovariectomized rats.
Author(s) -
FONSECA FABRICIA,
Mecawi Andre,
Araujo Iracema,
Monteiro Lívia,
Pereira Gislaine,
Rodrigues José,
Reis Luis
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.1058.1
Subject(s) - endocrinology , medicine , serotonergic , estrogen , chemistry , ovariectomized rat , basal (medicine) , endocrine system , serotonin , hormone , biology , receptor , insulin
Series of studies support an estrogen modulation upon the serotonergic system activity. Thus, we examined the endocrine response in ovariectomized (OVX) rats submitted to oil or estrogen treatment (OVX‐E2, 80microg/kg, SC, 14 days) and to treatment with the 8‐OH‐DPAT(250microg/kg, 7 days) or vehicle (0.9% NaCl) during 7 days), in basal condition and after sodium depletion. We also investigated a possible correlation between serotonergic functional status and E2 replacement on the plasma levels of angiotensin I and II(ANG I, II), oxytocin (OT) and corticosterone (CORT) in basal condition and after sodium depletion. The ANG I and ANG II release and respective mechanisms seem to be depending of the condition of the animal or 8‐OH‐DPAT treatment. Chronic 8‐OH‐DPAT in basal condition increased the ANG I plasma concentration while the E2 seems to attenuate this response following sodium depletion. The OT and CORT plasma levels at basal condition were enhanced by association of the two treatments. E2 replacement, both at baseline and depletion conditions, increased OT and CORT plasma levels. Additionally we did not observe estrogen influence on plasma CORT concentrations following sodium depletion. Both serotonergic signaling as estrogen may be considered controlling systems of electrolyte homeostasis.