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Cardiovascular Risk Related to Body Fat and Physical Activity in Young Girls
Author(s) -
Bea Jennifer,
Lee Vinson,
Blew Robert,
Funk Janet,
Going Scott
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.1055.17
Subject(s) - medicine , anthropometry , endocrinology , physical activity , cholesterol , physical therapy
Adiposity has been associated with cardiovascular (CVD) risk factors in children, but whether moderate to vigorous physical activity (MVPA) affects the association remains unclear. PURPOSE To determine if MVPA modifies associations between total body fat (TBF) and CVD risk biomarkers of C‐reactive protein (CRP); total (TC), LDL, and HDL cholesterol; triglycerides (TG), and glucose in girls aged 9‐12 years (N=95). METHODS Fasting serum CRP was measured by high‐sensitivity nephelometric bead‐based immunoassay; glucose and lipids were measured by clinical laboratory. Dual energy X‐ray absorptiometry estimated TBF. MVPA was assessed by the Past Year Physical Activity Questionnaire. Maturity offset was computed using age and anthropometric measures according to the Mirwald equation. RESULTS Mean age and maturity offset were 11.1 ± 1.1yrs and ‐1.83 ± 0.86yrs, respectively. Average TBF was 16.7 kg ± 11.0kg, while %TBF was 33.0 ± 10.6%. Mean MVPA was 45.8 ± 68.2 minutes/day. After controlling for maturity offset in linear regression models, %TBF was positively associated with CRP (β= 0.60, P<0.001), glucose (β=0.24, P=0.02), TC (β=0.29, P<0.01), TG (β=0.31, P<0.01), and LDL (β=0.43, P<0.001). HDL cholesterol was inversely associated with %TBF (β= ‐0.39, P<0.001). When stratified by adequate (蠅60min/d, N=21) versus inadequate MVPA (N=74), %TBF remained significantly associated with all CVD risk biomarkers (P蠄0.05) among those with adequate MVPA, with the exception of glucose. CONCLUSION Physical activity may help mediate the effects of body fat on glucose, but it did not attenuate the relationship between body fat and most cardiovascular risk factors among the girls. Supported by NIH HD074565