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Effects Of Aqueous Extracts Of The Leaves Of Millettia Aboensis On The Liver Of Wistar Albino Rats
Author(s) -
OnyegemeOkerenta Blessing
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.1023.2
Subject(s) - alkaline phosphatase , aqueous extract , alanine aminotransferase , chemistry , body weight , liver function , enzyme , liver enzyme , traditional medicine , toxicity , enzyme assay , medicine , biochemistry
The effect of aqueous extracts of the leaves of Millitia aboensis on the liver of Wistar albino rats was investigated. The experimental animals was divided into six groups (groups 1‐6) based on their body weight. Groups 1 ‐ 5 were administered with 1000, 2000, 3000, 4000 and 5000 mg/kg body weight of the extract respectively while group 6 (positive control) was given normal feed and water. The administration of the extract was for 7days and thereafter, the rats were sacrificed and the effects of the plant extract on the liver investigated. Liver function tests and histological examinations of the liver were carried out. Results for liver enzyme assay showed that aspartate aminotransferase (AST) activity significantly increased (p<0.05) in the different groups as compared to the control group (200±4.06 IU/L). It was observed that enzyme activity increased with increase in the of the extract concentration. Activities of alanine aminotransferase (ALT) for group 1 to group 5 ranged from 49.9±0.64 IU/L to 80.2±0.71 IU/L. For alkaline phosphatase (ALP), activities of the enzyme for group 1 to group 5 ranged from 150.5±9.92 to 483±10.82. The results of this study suggest that aqueous leaf extract of M. aboensis was hepatotoxic to Wistar albino rats, and toxicity was dose dependant