Premium
Ventral Respiratory Column Expiratory Neuron Activity is Altered during Fictive Swallow in the Cat
Author(s) -
Zhou Guannan,
Tsai HsiuWen,
Horton KofiKermit,
Morris Kendall,
Gestreau Christian,
Nuding Sarah,
Segers Lauren,
Lindsey Bruce,
Bolser Donald,
Davenport Paul
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.1012.12
Subject(s) - breathing , neuroscience , expiration , premovement neuronal activity , cats , chemoreceptor , medicine , neuron , respiratory system , biology , anatomy , receptor
Swallow and breathing are both fundamental functions for mammals. Anatomically, breathing and swallow share a common passageway, the pharynx. To coordinate with swallow and prevent aspiration, inspiration is inhibited, while expiration is prolonged. The swallow central pattern generator (sCPG) and the rCPG share common neural components. We hypothesize that the respiratory neuronal network in the VRC, has neurons that will be retasked during swallow to participate in production of the swallow breathing pattern. We stimulated the superior laryngeal nerve (SLN) of paralyzed, decerebrated, ventilated cats to elicit swallow. Extracellular neuronal activity was recorded with microelectrode arrays during fictive swallow and breathing. SLN elicited fictive swallow inhibited phrenic nerve activity and remodeled activity of expiratory neurons (E neurons) in the VRC. During fictive swallows, the activity of a subpopulation of expiratory decrementing (E‐Dec) neurons was suppressed, and a subpopulation of E‐Dec neurons was facilitated. Similar responses have been seen in different subgroups of expiratory augmenting (E‐Aug) neurons during fictive swallows. These results suggest that the VRC E neurons underwent reconfiguration to generate a coordinated swallow breathing pattern. The various response categories suggest that the E neurons located in the VRC are functionally heterogenous.