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Foot muscle of the sea slug Aplysia californica expresses a 5‐HT2 serotonin receptor (LB83)
Author(s) -
Duclos Laura,
Schuman Ben,
McPherson Duane,
Lovett Janice
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb83
Subject(s) - aplysia , serotonin , serotonergic , receptor , biology , 5 ht receptor , endocrinology , adenylyl cyclase , medicine , anatomy , neuroscience , biochemistry
Foot muscle of the sea slug Aplysia californica expresses a 5‐HT 2 serotonin receptor Laura Duclos*, Ben Schuman, Duane McPherson, Janice Lovett: Geneseo, NY 14454, Department of Biology, SUNY Geneseo Serotonin (5−HT) has strong modulatory effects on foot and body‐wall muscle in the opisthobranch slug Aplysia . These effects include increased force of muscle contraction and increased rate of muscle relaxation. At the cellular level, 5−HT causes a dose−dependent increase in the cyclic adenosine monophosphate (cAMP) content of foot muscle. Our laboratory has previously isolated and cloned from Aplysia foot a serotonin receptor belonging to the 5−HT 7 family, which stimulates adenylyl cyclase and could account for the increase in cAMP. More recently, a 5−HT2 receptor has been cloned from sensory neurons in the CNS of Aplysia (Nagakura et al., 2010). Using the information from that receptor sequence, we have discovered that foot muscle in Aplysia also expresses a 5−HT2 receptor. We are presently at work to clone the complete mRNA for this receptor, to determine whether it is identical to the one previously described. It is possible that 5−HT 2 and 5−HT 7 receptors act synergistically in the serotonergic modulation of muscle function.