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Relation of genetic polymorphisms and nutrient with bone density and skeletal muscle mass in Japanese young women (LB805)
Author(s) -
Kondo Hiroyo,
Fujino Hidemi,
Nagatomo Fumiko,
Ishihara Akihiko
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb805
Subject(s) - endocrinology , medicine , calcitriol receptor , sarcopenia , bone density , skeletal muscle , bone mineral , osteoporosis , single nucleotide polymorphism , bone remodeling , peak bone mass , vitamin d and neurology , biology , genotype , genetics , gene
Osteoporosis and sarcopenia are complex diseases characterized by low bone density and muscle mass, respectively, The purpose of this study was to assess the interactive effects of habitual exercise, nutrient intake and gene polymorphisms of Vitamin D receptor (VDR), estrogen receptor alpha (ESR1) and ciliary neurotrophic factor (CNTF) on bone density and skeletal muscle mass. 240 Japanese healthy young women (20‐23 yr) were recruited in this study. Habitual exercise and nutrient intake were assessed using a questionnaire. Bone density and muscle mass were measured by a quantitative ultrasound method and whole body impedance, respectively. In addition, the polymorphisms of ESR1, VDR and CNTF were genotyped using a TaqMan based real‐time PCR method. The skeletal muscle mass was correlated with calcium intake although there was no relationship between protein intake. Interestingly, the subjects with ESR1 allele A and VDR allele C in the habitual exercise subjects had significantly higher bone density than those in the non‐habitual exercise subjects . In addition, the skeletal muscle mass in non‐habitual exercise subjects with AA homozygote in CNTF was higher than that in TT. Thus, habitual exercise and calcium intake are more important for bone metabolism and skeletal muscle mass carrying ESR1 A and VDR C, allele. These results suggest that genetic polymorphisms were significantly associated with bone density and muscle mass in young women. Supported by Grants‐in‐Aid for Science Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology. Grant Funding Source : Supported by Japanese MEXT