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Interaction between genetic background and training intensity influences training responses (LB802)
Author(s) -
Avila Joshua,
Kim Seung,
Massett Michael
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb802
Subject(s) - sed , plantaris muscle , high intensity interval training , treadmill , strain (injury) , continuous training , interval training , skeletal muscle , intensity (physics) , medicine , biology , endocrinology , physical therapy , zoology , soleus muscle , physics , quantum mechanics
The aim of this study was to determine the intensity of exercise training that is required to maximize training adaptations in low responding mice. Male mice from three inbred strains: SJL/J, C57BL/6J, and NON/ShiLtJ completed a graded exercise test before and after four weeks of treadmill running. Mice from each strain were assigned to one of three groups (n=6/group): sedentary control (SED), continuous running (65% of max) and high‐intensity interval training (HIT) (6 x 85% of max for 8 min, 50% of max for 2 min). Exercise capacity was improved by continuous running compared with SED in mice from all strains (P < 0.05). For HIT, only NON/ShiLtJ mice showed a significant improvement in exercise capacity relative to SED mice from that strain. Protein content for PGC‐1alpha, NRF‐1 and mtTFA was examined in plantaris muscle to assess the metabolic adaptation to the different intensities of exercise training. Overall, exercise training induced relatively small changes in protein content in the plantaris. For SJL/J and NON/ShiLtJ, PGC‐1alpha tended to be double in plantaris from HIT compared with sedentary and unchanged in plantaris from C57BL/6J. Tfam protein content was also nearly double in muscle for HIT in SJL/J and C57BL/6J strains compared with sedentary. These data indicate that adaptations to training in skeletal muscle proteins are not directly related to changes in exercise capacity. Grant Funding Source : Supported by NIH grant HL085918 to MPM