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Deep Brain Stimulation of the ventral striatum impairs extinction of morphine place preference (LB76)
Author(s) -
Miranda Janelle,
Martinez Freddyson,
Rodríguez José,
Do Monte Fabricio,
Muñiz Oscar,
Quirk Gregory,
Barreto Jennifer
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb76
Subject(s) - deep brain stimulation , extinction (optical mineralogy) , conditioned place preference , striatum , morphine , ventral striatum , neuroscience , addiction , psychology , dorsum , stimulation , medicine , anesthesia , dopamine , chemistry , anatomy , parkinson's disease , mineralogy , disease
Deep brain stimulation (DBS) is a neurosurgical procedure in which implanted electrodes deliver electrical pulses to specific brain areas to treat movement disorders. Recently, DBS has been used to treat neuropsychiatric conditions such as obsessive‐compulsive disorder, depression and addiction. Addiction, a worldwide relapsing brain disorder, has been suggested as a promising target for the use of DBS in humans. The ventral striatum (VS) a key component of the brain reward circuit has been suggested as a potential DBS target for the treatment of refractory addiction. We recently found in rats that high frequency DBS (HF‐DBS) of the dorsal portion of the ventral striatum (dorsal‐VS) impaired the extinction of morphine‐induced conditioned place preference (CPP). Here, we examined whether HF‐DBS of the ventral region of the VS (ventral‐VS) could reduce the expression of morphine‐CPP and enhance its extinction learning. Since the VS is subdivided into anatomical and functional regions, we expect that HF‐DBS to the ventral‐VS, as opposed to the dorsal‐VS, will facilitate the extinction of morphine‐CPP. Similar to the DBS of the dorsal‐VS, our preliminary data showed that DBS of the ventral‐VS caused a non‐significant trend to impair the extinction of morphine place preference. This was indicated by the high percent of time the rats spent in the morphine‐paired side throughout extinction of the DBS group. These results suggest that ventral striatum DBS may not be a promising target for the treatment of extinction of opioid seeking behaviors. Grant Funding Source : This work was supported by RCMI Small Grants NIHNCRR (2G12‐RR003051) and NIMHD (8G12‐ MD007600) to JLBE, NIMH Conte Center (P50 MH086400‐Project 4) to GJQ and MBRS‐RISEMSC Fellowship (R25‐GM061838) to FJMR