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Catecholaminergic (CA) neurons modulate hypoxic ventilatory response in newborn rats (P7‐8) (LB737)
Author(s) -
Patrone Luis,
Bícego Kênia,
Gargaglioni Luciane
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb737
Subject(s) - catecholaminergic , hypoxic ventilatory response , catecholaminergic cell groups , endocrinology , hypoxia (environmental) , medicine , excitatory postsynaptic potential , tyrosine hydroxylase , respiratory system , anesthesia , chemistry , catecholamine , dopamine , inhibitory postsynaptic potential , organic chemistry , oxygen
CA neurons are involved in autonomic and respiratory regulation during low O 2 conditions in adult mammals. We evaluated the participation of central CA neurons of neonate male and female rats (P7‐8) in the hypoxic ventilatory response (HVR) by specifically lesioning them with antidopamine beta‐hydroxylase‐saporin (DBH‐SAP, 42ng / 100nL) injected via the 4th ventricle. Minute ventilation (VE) of newborn was recorded by pressure‐plethysmography from the body chamber during normoxia and hypoxia (10%O 2 ). HVR was reduced significantly (~23%) in male and female lesioned newborn rats (male‐ control group: 137.6±6.4 (% of baseline) vs lesioned group: 104.3±1.4 (% of baseline), p <0.01; female‐ control group: 131±1.0 (% of baseline) vs lesioned group: 102.6±2.6 (% of baseline) p <0.02). These results suggest that catecholaminergic neurons exert an excitatory modulation in newborn rats in O 2 chemosensitivity. Grant Funding Source : Fapesp and CNPq