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The effect of protein on postprandial endothelial function after a high‐fat meal. (LB691)
Author(s) -
Phillips Michelle,
Offerdahl Ali,
Hunt Brian
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb691
Subject(s) - postprandial , meal , endothelial dysfunction , medicine , brachial artery , endothelium , ingestion , nitric oxide , endocrinology , blood pressure , insulin
Meals high in fat depress nitric oxide production by endothelial cells for several hours after the meal. Thus, perpetual ingestion of these meals can promote the development of atherosclerosis and cardiovascular disease. Recent research has shown the addition of a large quantity of protein to a high fat meal can prevent the postprandial decline in endothelial function. The purpose of this study is to determine if a 1‐to‐1 or a 1‐to‐2 protein‐to‐fat ratio can reduce postprandial endothelial dysfunction after a high‐fat meal. METHODS: 10 males, ages 18‐22, participated in this study. After an overnight fast each participant was given either a high fat meal (HF), a high fat + low protein meal (HFLP), or a high fat + high protein meal (HFHP). The meal order was counterbalanced among participants. Endolethium‐dependent, nitric oxide‐mediated dilation of the brachial artery was measured using flow‐mediated dilation (FMD) immediately before and 60 minutes after each meal. For this preliminary data analysis we used a one‐tailed, repeated measures t‐test (p<0.05) to determine if there was a significant decline in postprandial FMD after each meal. RESULTS: After HF, FMD was lower ‐3.8%±1.9 (p=0.01). After either HFLP or HFHP, FMD was not lower (+1.5±0.8%; p=0.98 and +1.7±1.3%; p=0.79 respectively). CONCLUSION: A protein to fat ratio of 1‐to‐2 is adequate to prevent the postprandial decline in endothelial function typically seen after a high‐fat meal.