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Renal denervation changes hemodynamic response to losartan in SHR rats (LB651)
Author(s) -
Skrzypecki Janusz,
Drapala Adrian,
Sikora Mariusz,
Ufnal Marcin
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb651
Subject(s) - losartan , denervation , medicine , blood pressure , renal artery , antihypertensive drug , hemodynamics , endocrinology , renal sympathetic denervation , angiotensin ii , kidney , renal blood flow , urology , cardiology , resistant hypertension
Efficacy of renal denervation in the treatment of drug‐resistant hypertension is currently under debate. Recently, SIMPLICITY III study showed that the combined therapy with renal denervation and antihypertensive drugs is not superior to appropriate pharmacotherapy alone. In this study we checked if renal denervation affects hypotensive effect of losartan, an angiotensin II type 1 receptor blocker, in Spontaneuosly Hypertensive Rats (SHR). We exposed renal arteries from extraperitoneal access. In the study group all visible nerves adjacent to renal arteries were dissected and then the arteries were wiped with 5% phenol in absolute ethanol. In controls renal arteries were left intact. In both groups we implanted subcutaneously osmotic minipumps releasing either losartan or 0,9% NaCl. One week later we measured mean arterial blood pressure (MABP) and heart rate (HR) in conscious rats. We found that losartan produced greater decrease in MABP than renal denervation. Rats treated with renal denervation and losartan exhibited similar decrease in MABP to rats treated with losartan alone. Interestingly, treatment with losartan alone significantly increased HR while renal denervation combined with losartan did not affect HR. In conclusion, this study shows that combined renal denervation and pharmacotherapy may produce different hemodynamic effects than pharmacotherapy alone. Grant Funding Source : Supported by the Ministry of Science and Higher Education Republic of Poland, Diamond grant DI2012 008042