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Mutagenic modification effect of pomegranate juice in nitrite treated aminopyrene using Ames test (LB640)
Author(s) -
Tongyonk Linna,
Siritientong Tippawan,
Tansawat Rossarin
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb640
Subject(s) - nitrite , chemistry , ames test , food science , sodium nitrite , salmonella , mutagen , biochemistry , bacteria , biology , carcinogen , nitrate , organic chemistry , genetics
This study evaluated the direct mutagenicity of fresh, and sterilized pomegranate juices and their modification effect on mutagenesis induced by nitrite treated 1‐aminopyrene in the absenceof metabolic activation on Salmonella typhimurium strains TA 98 and TA100. It was found that fresh juice was not mutagenic on both strains either with or without nitrite treatment. But the highest amount (24.67 mg/plate) of sterilized sample after being treated with nitrite exhibited slight mutagenicity on TA 98. Fresh pomegranate juice did not show antimutagenic activity against nitrite treated 1‐aminopyrene. In addition, it presented co‐mutagenic effect. Sterilized pomegranate juices kept for 0, 30 and 90 days were also evaluated for their antimutagenicity. It was found that sterilized sample kept for 90 days exhibited weak antimutagenic activity against nitrite treated 1‐ aminopyrene on TA 98. The results obtained from the present experimental condition revealed that antimutagenic activity of pomegranate juice is not clear.Further studies will be needed to investigate the antimutagenicity potential of pomegranate juice.