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Vanillins relax isolated porcine coronary arterial smooth muscle by inhibiting L‐type Ca 2+ channels (LB574)
Author(s) -
Raffai Gábor,
Kim Jihye,
Khang Gilson,
Lee Dongwon,
Vanhoutte Paul
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb574
Subject(s) - apocynin , chemistry , vanillin , pharmacology , glibenclamide , apamin , oxidative stress , medicine , biochemistry , endocrinology , nadph oxidase , calcium , organic chemistry , diabetes mellitus
Vanillin (VA) and vanillyl alcohol (VAA) are major components of natural vanilla, while ethyl vanillin (EtVA) is a synthetic vanillin analog with antioxidant and anti‐inflammatory properties. This study compared the relaxing effect of vanillins (VA, VAA, EtVA) and poly(vanillin) oxalate (PVO) nanoparticles (Ø 260nm) containing VA in porcine coronary artery rings by measuring isometric tension. Vanillins but not PVO caused concentration‐dependent, endothelium‐independent and complete relaxations during contractions to U46619, KCl or endothelin‐1 with an order of potency of VAA