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HDL from Patients with Inflammatory Disorders has High levels of Oxidized Lipids and is Dysfunctional (LB536)
Author(s) -
Bakhtiari Persiah
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb536
Subject(s) - paraoxonase , dysfunctional family , medicine , population , cholesterol , inflammation , aryldialkylphosphatase , oxidative phosphorylation , endocrinology , oxidative stress , pon1 , chemistry , biochemistry , gene , psychiatry , environmental health , genotype
HDL from Patients with Inflammatory Disorders has High levels of Oxidized Lipids and is Dysfunctional. Persiah Bakhtiari, Omeed El Boudvarej MD, Susan Hama, Nasim Pourtabatabaei MD, Sheila Safar MD, Samra Vazirian MD, Seyedehsara Seyedali MD, Sepideh Madahian MD, Greg Hough . David Geffen School of Medicine at UCLA, Los Angeles California, 90095 Population studies have shown that plasma levels of HDL inversely correlate with the prevalence of coronary heart disease. HDL levels in an individual does not necessarily correlate with the risk for coronary heart disease. Many patients with high HDL, present with coronary events and many with low HDL do not. We demonstrated that HDL composition and function is important than HDL levels. Under excessive inflammatory pressure unsaturated fatty acids can undergo oxidative modification. Protective enzymes including paraoxonase, LCAT and PLTP are inactivated by oxidative modification reducing HDL anti inflammatory properties. This results in HDL not being able to protect LDL from oxidative modification. Methods: Fasting plasma from patients with coronary disease were analyzed for their ability to prevent LDL modification. Additionally the content of oxidized lipids in HDL was determined using LC‐ESI‐MS/MS. Results: Among coronary patients over 69 percent had non protective HDL while among healthy controls 4.5 percent had dysfunctional HDL. The content of a variety of oxidized lipids in the HDL from patients was orders of magnitude higher than that found in HDL from normal Controls. Conclusion: Until there are effective medications for raising HDL, it should be clear to the public that the best way of dealing with low HDL cholesterol is lowering LDL cholesterol.