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Macrophage migration inhibitory factor has a role controlling colorectal cancer (LB491)
Author(s) -
RodriguezSosa Miriam,
PachecoFernández Thalia,
JuárezAvelar Imelda,
RodríguezMonroy Marco,
NietoYañez Oscar,
Chirino Yolanda,
LeónCabrera Sonia,
PérezPlasencia Carlos,
AvilaMoreno Federico,
Terrazas Luis
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb491
Subject(s) - macrophage migration inhibitory factor , azoxymethane , inflammation , colorectal cancer , cytokine , cancer research , immunology , chemokine , tumor necrosis factor alpha , cancer , immune system , metastasis , medicine , angiogenesis
Chronic inflammation has been related with cancer development by counteracting and unbalancing the immune response. The inflammatory cytokine macrophage migration inhibitory factor (MIF) is overexpressed in many carcinogenic tumors, stimulates angiogenesis and metastasis promoting proliferation and survival in malignant cells. In the inflammatory disease ulcerative colitis MIF is early expressed and favors the inflammatory cytokine production like TNF‐α, and IL‐1β. As intestinal chronic inflammation may proceed to colorectal cancer, we are interested in determining the role of MIF on development and pathology on colorectal cancer. To elucidate this point we used MIF‐KO and WT mice, both with BALB/c genetic background, to develop a colorectal cancer model of Dextran Sodium Sulfate and Azoxymethane. As expected, MIF‐KO mice showed low levels of serum inflammatory cytokines TNF‐α, IL‐1β and IFN‐γ compared to WT mice. Strikingly, we found significantly more tumor and in a higher development stage on MIF‐KO mice (24.4+/‐2) compared to WT mice (12.6+/‐2). Higher number of activated macrophages and NK cells were detected in intestinal epithelium on WT mice compared to MIF‐KO mice. Therefore, although MIF has been recognized as a promoter of inflammation, which could favor the development of cancer; our results suggest that MIF is involved in controlling the development of colorectal cancer, possibly by its chemokine properties. Grant Funding Source : Supported by CONACyT (152224) and PAPCA‐2013. The student TPF holds a scholarship from CONACyt, #20465.