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Factors associated with maternal weight gain rate throughout pregnancy in women with normal and excessive pre‐pregnancy weight (LB446)
Author(s) -
FrancoSena Ana Beatriz,
Rebelo Fernanda,
Pinto Thatiana,
Farias Dayana,
Mendes Roberta,
Teixeira Viviana,
Silveira Gabrielle,
Kac Gilberto
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb446
Subject(s) - medicine , overweight , body mass index , pregnancy , weight gain , obesity , prospective cohort study , leptin , endocrinology , obstetrics , normal weight , body weight , biology , genetics
Objective: To evaluate the effect of leptin and other selected variables on maternal weight gain rate (MWGR) in women with normal and excessive pre‐pregnancy weights. Methods: A prospective cohort of 236 pregnant women was followed at the 5‐13th, 20‐26th and 30‐36th gestational weeks. The effects of independent variables on MWGR in normal weight (18.7kg/m2 蠄 Body Mass Index (BMI) < 25.0 kg/m2) and overweight/obese (25.0 kg/m2 蠄 BMI 蠅 45.5 kg/m2) women were assessed using longitudinal linear mixed‐effects models. Results: In the final model of women with normal BMIs, the following covariates remained significantly associated with MWGR: leptin (β=0.053, SE=0.013), HDL‐c (β=‐0.075, SE=0.021), sleep duration (β=‐0.267, SE=0.083) and maternal height (β=0.687, SE=0.071). For overweight/obese women, the associated variables were HDL‐c (β=‐0.069, SE=0.025), fasting glucose (β=‐0.066, SE=0.021), smoking habit (former smoker: β=‐4.555, SE=2.301) and maternal height (β=0.808, SE=0.151). Conclusion: Leptin presented an effect on MWGR in normal weight women but not in overweight/obese women. The HDL‐c levels and maternal height were associated with MWGR throughout pregnancy in both BMI categories. The effect of the duration of sleep on MWGR was only observed in normal weight women, and the effects of fasting glucose concentrations and smoking habits were specific to overweight/obese women.