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Decreasing the biological drive toward weight gain by increasing energy flux (LB431)
Author(s) -
Foright Rebecca,
Paris Hunter,
Werth Kelsey,
Larson Lauren,
Beals Joseph,
Wilburn Jessie,
Davis Janelle,
Bell Christopher,
Melby Christopher
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb431
Subject(s) - resting energy expenditure , weight loss , zoology , energy expenditure , energy balance , flux (metallurgy) , medicine , body weight , weight gain , endocrinology , obesity , chemistry , biology , ecology , organic chemistry
Weight regain after weight loss is the experience of most obese dieters. Metabolic adjustments characterized by decreased resting energy expenditure (REE) and increased hunger can prevent long‐term success. Possibly this energy gap could be attenuated by a high flux (HF) state (higher expenditure coupled with higher intake). Methods: 5 obese adults [age (x̅ ± SD) =46±10 BMI=35.0±3.7 kg/m 2 ] underwent 7% weight loss and were stabilized at this weight for 3 weeks. REE via indirect calorimetry, and hunger via visual analog scale were then examined during two 4‐day conditions of energy balance in random order: Low Flux (LF)‐Sedentary with energy intake (EI)=REE x1.35; and HF‐Daily exercise net energy cost of ~500 kcal/d and EI= REE x1.7. Results: Average 5 day weight did not differ between HF (96.9kg) and LF (96.5kg) (p>0.10). Average daily REE was higher during HF (1816±227 kcal/day) compared to LF (1747±221 kcal/day) (p= 0.07). Average perceived hunger was lower during HF (93.9±24.1) compared to LF (93.8±7.0) (p= 0.056). Conclusion: These preliminary data suggest that high flux is associated with a greater REE and less hunger, which may protect against weight regain. Grant Funding Source : Supported by the Colorado Agricultural Experiment Station