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Oxidative stress is decreased with short‐term Protandim use when piperine is substituted for ashwagandha (LB399)
Author(s) -
Scalzo Rebecca,
Davis Janelle,
Beals Joseph,
Biela Laurie,
Giordano Gregory,
Paris Hunter,
Miller Benjamin,
Hamilton Karyn,
Bell Christopher
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb399
Subject(s) - piperine , oxidative stress , nutraceutical , traditional medicine , thiobarbituric acid , ingredient , chemistry , tbars , milk thistle , food science , pharmacology , medicine , biochemistry , lipid peroxidation
Ashwagandha is an active ingredient of Protandim, a commercially available, plant‐based nutraceutical that activates nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2). In some countries ashwagandha is considered medicinal and thus is subject to regulation. The purpose of this study was to evaluate the effect of Protandim without ashwagandha, and Protandim with piperine substituted for ashwagandha, on circulating markers of oxidative stress. 33 overweight/obese adults, aged 45‐69 years, were assigned to one of three 30‐day interventions comprising daily consumption of: placebo (PLAC: 719 mg maltodextrin), Protandim minus ashwagandha (P‐A: a blend of milk thistle extract, bacopa monnieri extract, green tea extract, turmeric powder, and maltodextrin), or Protandim with piperine substituted for ashwagandha (P+P). Compared with baseline, circulating plasma thiobarbituric acid reactive substances were unaffected by PLAC ( n =13; 4.70±0.44 vs . 6.09±0.84 nmol/mL; mean±SE), or P‐A ( n =7; 5.44±0.86 vs. 7.79±1.42 nmol/mL), but were decreased with P+P ( n =13; 6.31±0.91 vs. 4.90±0.47 nmol/mL); P =0.02. Nrf2 activation may provide protection from chronic diseases associated with increased oxidative stress. These preliminary data suggest, in countries where ashwagandha is considered medicinal, piperine may be an acceptable substitute ingredient in the Nrf2 activator, Protandim. Grant Funding Source : Supported by LifeVantage