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Association of Body Composition and Vitamin D Levels with Cardiac Geometric Pattern in Rheumatoid Arthritis Patients. (LB374)
Author(s) -
Azevedo Paula,
Batista Andrea,
Baccaro Antonio,
Narimatsu Karina,
Modesto Pamela,
Albano Aline,
Polegato Bertha,
Pereira Elenize,
Rocha Oswaldo,
Gradella Luciana,
Minicucci Marcos,
Zornoff Leonardo,
Zanati Silmeia,
Okoshi Marina,
Paiva Sergio
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb374
Subject(s) - medicine , ventricle , rheumatoid arthritis , concentric hypertrophy , cardiology , concentric , lean body mass , gastroenterology , left ventricular hypertrophy , body weight , geometry , blood pressure , mathematics
Chronic inflammation presented in rheumatoid arthritis (RA) is associated with systemic manifestations, that include micronutrient deficiency, changes in body composition and cardiac morphofunctional alterations. The aim of this study is to evaluate the association of serum vitramin D and body composition with cardiac geometric pattern in patients with RA. Methods: 30 patients with RA were submitted to clinical, nutritional and biochemical evaluation. Bioimpedance analysis and dual‐energy X‐ray absorptiometry (DEXA) was performed to evaluate body composition. Transthoracic dopller‐ echocardiography was performed to evaluate left ventricle mass and relative wall thickness (RWT) in order to find cardiac geometry patterns. Patients were divided in Normal or abnormal pattern (concentric remodeling or concentric hypertrophy.) Results: The mean age was 53±9 years; 70% were woman, 43% presented with hypertension. All patients have been treated with methotrexate and a biological agent and presented with Disease activity Score (DAS28) 2,7±1,2. Serum vitamin D (ng/mL) was 30± 10,Body composition showed: BMI (kg/m2 ) 26±6, abdominal circumference (cm) 96±12, hand grip (kgf) 19±4,6 ; fat mass evaluated by DEXA (%) 33,8 ± 9,5 and by bioimpedance (%) 34,7±8,3; phase angle 6,6±0,6. Normal Cardiac geometric pattern was observed in 45%, concentric remodeling in 31% and concentric hypertrophy in 24%. Multiple logistic regression showed that hypertension and phase angle explain abnormalities in geometric pattern, even when adjusted by age, gender and hypertension. Vitamin D correlated with RWT, however it is not associated with geometric pattern. Conclusion: phase angle may be a potential marker of cardiac geometric pattern in patients with RA. Grant Funding Source : FAPESP: Fundação de Amparo à Pesquisa do Estado de São Paulo