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Decrement of triglyceride accumulation of Coriander (LB352)
Author(s) -
Kang Soon Ah,
Kim MiJa,
Kim JongAe,
Kim HyunSook,
Jung Kwang_Gyun,
Kim SeongHee,
Kim Jinkyung
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb352
Subject(s) - coriandrum , dpph , abts , food science , triglyceride , chemistry , sativum , antioxidant , ascorbic acid , gallic acid , adipogenesis , traditional medicine , biochemistry , botany , in vitro , biology , cholesterol , medicine
Cells were fixed and stained with Oil Red O to assess lipid accumulation. Total lipid and triglyceride contents increased during the cell differentiation. Coriander ( Coriandrum sativum L. ) is widely cultivated in Russia, Central Europe, North Africa and Asia. It is valued for its medicinal uses. In this study, the antioxidant activities of Coriander were evaluated using in vitro system including DPPH, ABTS, and ORAC methods. Total phenolic contents of Coriander extract were 3.6 μmole quercetin equivalent/g raw sample and EC50 of Coriander extract for scavenging DPPH and ABTS radicals were 5.7 and 8.0 μmole ascorbic acid equivalent/g raw sample, respectively. Triacylglycerol content in 3T3‐L1 preadipocyte cells treated with 25, 50, and 100 μg/mL Coriander extract decreased significantly by 37.0, 55.7, and 69.8%, respectively (p<0.05) compared to those in untreated cells. Also, Coriander extract induced the down‐regulation of adipogenesis‐related genes such as PPARγ, GDP1 and FAS. The Coriander extract showed phenolic compounds with antioxidant ability and had in vitro decrement of triglyceride accumulation on 3T3‐L1 adipocyte cells. Grant Funding Source : Korean government (MEST)